Activated Charcoal Decreases Plasma Bilirubin Levels in the Hyperbilirubinemic Rat
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چکیده
منابع مشابه
Anti-genotoxic potential of bilirubin in vivo: damage to DNA in hyperbilirubinemic human and animal models.
The bile pigment bilirubin is a known antioxidant and is associated with protection from cancer and cardiovascular disease (CVD) when present in too strong concentrations. Unconjugated bilirubin (UCB) might also possess anti-genotoxic potential by preventing oxidative damage to DNA. Moderately elevated bilirubin levels are found in individuals with Gilbert syndrome and more severe in the hyperb...
متن کاملCerebellar hypoplasia in the hyperbilirubinemic Gunn rat: morphological aspects.
Gunn rats, a mutant strain of rats, suffer from autosomal recessive hyperbilirubinemia. The homozygotes (j/j) develop jaundice soon after birth and often exhibit kernicterus and cerebellar hypoplasia that are due to bilirubin. Therefore, j/j Gunn rats have been used as an animal model of bilirubin encephalopathy, as well as of neonatal hyperbilirubinemia. In this review, we discuss morphologica...
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Objectives: Jaundice is a main problem in the early neonatal period and it is suggested that there is a positive correlation between plasma ionized Mg levels and severity of hyperbilirubinemia in newborn. The aim of this study is to explore the association and to evaluate and interpret its clinical significance as well as to observe the effect of phototherapy on serum magnesium and bilirubin le...
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The use of activated charcoal in the radioimmunoassay of human growth hormone is described. The method permits the rapid separation of bound from free labelled human growth hormone in large batches and affords a quick method for screening iodination eluates. The necessity for an equality of protein concentration for the incubation and the separation procedure is emphasized. The method is simple...
متن کاملPrehospital activated charcoal: the way forward.
OBJECTIVES Single dose activated charcoal (SDAC) may be an effective method of gastric decontamination when administered to patients within an hour of drug overdose. However, few patients who may benefit from this treatment attend an emergency department within this timeframe. The authors sought to determine the current attitudes of ambulance NHS trusts to recent recommendations that the admini...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1983
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198303000-00008